Repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunction
نویسندگان
چکیده
منابع مشابه
Blast Exposure, White Matter Integrity, and Cognitive Function in Iraq and Afghanistan Combat Veterans
The long-term effects of blast exposure are a major health concern for combat veterans returning from the recent conflicts in Iraq and Afghanistan. We used an optimized diffusion tensor imaging tractography algorithm to assess white matter (WM) fractional anisotropy (FA) in blast-exposed Iraq and Afghanistan veterans (n = 40) scanned on average 3.7 years after deployment/trauma exposure. Vetera...
متن کاملRepetitive closed-skull traumatic brain injury in mice causes persistent multifocal axonal injury and microglial reactivity.
Repetitive mild or "concussive" traumatic brain injury (TBI) can cause substantial neurologic impairment, but the pathological features of this type of injury are not fully understood. We report an experimental model of TBI in which the closed skulls of anesthetized male C57BL/6J mice are struck with an electromagnetically controlled rubber impactor twice with an interval of 24 hours between im...
متن کاملCerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms.
Disagreement exists regarding the extent to which persistent post-concussive symptoms (PCS) reported by Iraq combat Veterans with repeated episodes of mild traumatic brain injury (mTBI) from explosive blasts represent structural or functional brain damage or an epiphenomenon of comorbid depression or posttraumatic stress disorder (PTSD). Objective assessment of brain function in this population...
متن کاملEarly adversity and combat exposure interact to influence anterior cingulate cortex volume in combat veterans☆
OBJECTIVE Childhood and combat trauma have been observed to interact to influence amygdala volume in a sample of U.S. military veterans with and without PTSD. This interaction was assessed in a second, functionally-related fear system component, the pregenual and dorsal anterior cingulate cortex, using the same sample and modeling approach. METHOD Anterior cingulate cortical tissues (gray + w...
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The Mars mission will result in an inevitable exposure to cosmic radiation that has been shown to cause cognitive impairments in rodent models, and possibly in astronauts engaged in deep space travel. Of particular concern is the potential for cosmic radiation exposure to compromise critical decision making during normal operations or under emergency conditions in deep space. Rodents exposed to...
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ژورنال
عنوان ژورنال: Science Translational Medicine
سال: 2016
ISSN: 1946-6234,1946-6242
DOI: 10.1126/scitranslmed.aaa9585